C'est quoi un gliome ?

C'est quoi un gliome ?

Le glioblastome est une tumeur maligne du cerveau. Cette pathologie touche le plus souvent les adultes de 45 à 70 ans, avec une moyenne d'âge de 58 ans. Elle touche plus fréquemment les hommes.

Comment Meurt-on d'une tumeur cérébrale ?

Quand le cerveau est touché, les métastases vont, en grossissant, provoquer des lésions vitales amenant au coma, puis au décès.

What are the symptoms of gliomas of the brain?

• Symptoms of gliomas depend on which part of the central nervous system is affected. A brain glioma can cause headaches, vomiting, seizures, and cranial nerve disorders as a result of increased intracranial pressure. A glioma of the optic nerve can cause visual loss.

What is the relationship between DNA damage and gliomas?

• This indicates that altered or deficient repair of DNA damage contributes to the formation of gliomas. DNA damages are a likely major primary cause of progression to cancer in general. Excess DNA damages can give rise to mutations through translesion synthesis.

What has changed in the who classification of especially diffuse gliomas?

• In the revised fourth edition of the WHO Classification of CNS tumours published in 2016, classification of especially diffuse gliomas has fundamentally changed: for the first time, a large subset of these tumours is now defined based on presence/absence of IDH mutation and 1p/19q codeletion.

What is the difference between Grade 1 and Grade 2 gliomas?

• Biologically benign gliomas [WHO grade I] are comparatively low risk and can be removed surgically depending on their location Low-grade gliomas [WHO grade II] are well-differentiated (not anaplastic ); these tend to exhibit benign tendencies and portend a better prognosis for the patient.